In this position the ESR will be employed by LUMC, a University Hospital dedicated to patient care, teaching and translation of scientific findings to the clinic. The ESR’s role in the project will be to investigate the mechanisms of action of MSC by determining their effect on renal vascular endothelial and proximal tubular cells. More specifically:
- Develop ultrasound/2-photon intravital microscopy strategies for in vivo renal vasculature assessment.
- Implement mouse models to study the effect of MSC on vascular endothelial and proximal tubule cells, including evidence for mitochondrial transfer.
- Investigate repair mechanisms to determine the effect of MSC and MSC-derived extra cellular vesicles on key signalling pathways implicated in vascular endothelial and tubular cell injury and repair.